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The undeclared active pharmaceutical ingredients in some of these products include sibutramine (a controlled substance), rimonabant ( a drug not approved for marketing in the United States), phenytoin ( an anti-seizure medication), and phenolphthalein (a solution used in chemical experiments and a suspected cancer causing agent). Those trials compared taking rimonabant (20 milligrams a day) against a placebo. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added.

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